Sr Research Associate 1, Oligonucleotide bioconjugate production
San Rafael, CA
We are seeking a highly motivated and experienced Senior Research Associate to join the Oligonucleotides and Drug Delivery group. Through internal and external\u00A0partnerships,\u00A0the Oligonucleotides and Delivery group\u00A0aims to discover new oligonucleotide therapies and efficiently target them to specific tissues, maximizing therapeutic effect while limiting off-target toxicity. This position offers a unique career opportunity to work on diverse projects from exploratory research through late-stage programs in a variety of indications. Correspondingly, there will be many opportunities to learn new skills and techniques as project needs arise. The successful candidate will be curious and motivated to approach each challenge as a new learning opportunity. The candidate will interact with all facets of Research and Early Development to advance our most promising research programs for rare diseases. This Senior Research Associate position will report to a Scientist in the Oligo and Delivery team and will have the opportunity to influence the evolution of this team\u00A0in a growing biotech company.The Senior Research Associate will contribute to scientific innovation by production and characterization of oligonucleotide-based therapies. Extensive experience in oligonucleotide and protein purification including IEX, SEC, HIC, affinity, HPLC, and other\u00A0chromatographic methods is required. Prior experience in biophysical and analytical methods such as CE, cIEF, SECMALS, SPR, BLI, native/SDS-PAGE, agarose gel electrophoresis, etc. is required. The ideal candidate is highly motivated and able to work both independently as well as in a team environment. The candidate will be involved in various projects that involve presenting data to collaborators and will assist in writing reports and preparing presentations by organizing data and observations.\u00A0Responsibilities:Optimize pilot and intermediate scale purification of oligonucleotide-based drug candidatesPerform bioanalytical and biophysical techniques to characterize oligonucleotide-based drug candidatesFormulate and quality control test articles for in vitro and in vivo studiesCollaborate with internal and external partners for material transferPerform data analysis, interpret, and present results during internal and external meetingsPrepare SOPs and other documents such as data reports for testing resultsParticipate and present data and\u00A0share responsibility for project milestonesGeneral lab duties and notebook documentation of experimentsSkills:Experience in liquid chromatography for analytics and purification (HPLC/FPLC) is requiredExperience in analytical techniques relating to oligonucleotide, protein, and bioconjugate characterization is requiredExperience in quantitative assays for oligonucleotides and proteins is desired Detail oriented, organized, and experienced at executing experiments in the labDemonstrate an ability to work as part of a team and possess an excellent work ethicEducation and experience:Bachelors with minimum of 6 years of experience or Master with minimum of 4 years of experience in Analytical, Molecular Biology, Biochemistry, or related field.\u00A0PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19.We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.\u00A0
|
