Scientist 1-2, Drug Substance Technology - Downstream
Novato, CA
Who We Are For more than two decades, going our own way has led to countless breakthroughs, bettering the lives of those suffering from rare genetic disease. In 1997 we were founded to make a big difference in small patient populations. Now we seek to make an even greater impact by applying the same science-driven, patient-forward approach that propelled our last 25 years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Through our unparalleled expertise in genetics and molecular biology, we will continue to develop targeted therapies that address the root cause of the conditions we seek to treat. Applying our knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The end goal has always been better lives and now we can reach more. And the more people we reach, the more our impact can grow. We transform lives through genetic discovery. Our Culture Our desire to make a positive impact on our patients extends to our employees and BioMarin is committed to fostering an inclusive environment where every person feels seen, valued, and heard \u2013 so employees can thrive in all areas of their lives, in and outside of work. We seek to provide an open, flexible, and friendly work environment to empower people and to provide them with the ability to develop their long-term careers. Ultimately, we want to be an organization where people enjoy coming to work and take pride in our efforts to help patients. BioMarin\u2019s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin\u2019s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients\u2019 lives. SUMMARYThe Scientist is responsible for the development and characterization of purification processes for therapeutic proteins and gene therapy vectors, and for their implementation in manufacturing facilities.\u00A0RESPONSIBILITIESThe Scientist has expertise relevant to the development of purification processes for therapeutic proteins and gene therapy vectors. Working as part of a team, the Scientist strives to design individual process steps and to assemble them into complete processes that meet regulatory requirements and expectations for efficiency and product quality.On a hands-on basis, the Scientist\u00A0\u00A0\u00A0\u00A0\u00A0\u00A0\u00A0\u00A0 designs and carries out experiments; develops and makes use of analytical methods, chiefly HPLC, ddPCR, SDS-PAGE, Western blots, ELISA, and enzyme activity assays; runs larger-scale purification trains to provide experimental supplies to other groups; takes part in process troubleshooting, and transfer of processes to large-scale manufacturing facilities; and communicates with others via presentations and written reports on process descriptions, technical progress, milestones, and challenges.\u00A0The Scientist primarily will work as an individual contributor, but with time may lead a development group of one or more research associates.\u00A0\u00A0 \u00A0EXPERIENCERequired Skills:The applicant\u2019s chief job responsibilities have to do with protein and viral vector purification projects. Thus, the candidate should have practical experience in the development of methods for purifying proteins or vectors using unit operations such as chromatography, filtration, and ultrafiltration. \u00A0The essential function of the job is experimental investigation. The applicant should have advanced skills in experimental design, data analysis, and data presentation.\u00A0 The Scientist should be capable of generating quality scientific data with limited assistance from coworkers. Evidence of independent scientific thought, as evidenced by original peer-reviewed scientific publications or conference presentations, is desired.\u00A0Desired Skills:Industry experience in purification process development on AAV viral vectors and monoclonal antibodies.Experience in preparative chromatography and density gradient ultracentrifugation.Demonstrated expertise in protein chemistry and/or viral vector structure and function.Led or mentored one or more research associates. \u00A0EDUCATIONA Ph.D. degree in chemistry, biochemistry, chemical engineering, or the biological sciences is requiredScientist 1: Ph.D. with 0-2 years of relevant industry experience Scientist 2:\u00A0Ph.D. with 2-5 years of relevant industry experience\u00A0EQUIPMENTLaboratory equipment, such as analytical instruments and chromatography workstations; pilot processing equipment, such as pumps, filtration devices, and chromatography skids.\u00A0CONTACTSOther scientists and senior scientists within Technical Development, Research, Quality Control, and Manufacturing Science and Technology; project managers, and laboratory associates.\u00A0SUPERVISOR RESPONSIBILITYNone PLEASE NOTE: Absent a Medical or Religious reason that prohibits vaccinations, all our incoming employees must be vaccinated for COVID-19. We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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